Infusan Magnesium Sulfate Heptahydrate Drug Interactions

This product should be administered with care when coadministered with Ritodrine hydrochloride.
Magnesium salt should be administered with caution in patients treated with cardiac glycosides, since heart block may occur if calcium salt are required to treat magnesium toxicity.
Concurrent use of Magnesium Salt and CNS depressant drugs may result in an enhanced CNS depressant effect.
Concurrent use of Magnesium Salt with neuromuscular blocking agents may result in an excessive neuromuscular blockade.
Concurrent use of Magnesium Sulfate and nifedipine may result in an exaggerated hypotensive response.
Clinical symptom: Creatine phosphokinase (CPK) levels may increase.
Mechanism and risk factors: The mechanism for the increase in CPK with threatened premature delivery.
Incompatibilities: Magnesium Sulfate is incompatible with Calcium Salts. Calcium Sulfate may precipitate when Calcium Salt are mixed with Magnesium Sulfate in the same i.v. solution.
Magnesium salt have also been reported to be incompatible with alkaly carbonates and bicarbonates and soluble phosphates.